energetics of assembly and genome packaging of bacteriophages

Author: Tsotne Dvali
Keywords: bacteriophages, biosystem, packaging, thermodynamics, biophysics
Annotation:

The energy of the bacteriophage assembly process is discussed through various existing models [Sarah Katen., 2010], analysis of genome co-axial and toroidal conformation models using existing experimental and therapeutic materials. The dependence of the parasitic activity of bacteriophages on the low energy value of their constituents is considered. The mechanism of genome packing is imprinted as a process of energy storage and conversion against background bacterial metabolic processes. The force produced in the packaging process (spread on DNA) is reduced to 50-120 pn, according to experiments conducted in a simulated environment, which allows the energy for the three target bacteriophages T4, T7, Phi29 to be stored in the structure in the form of three spells. The contribution of osmotic pressure to the injection process is also noted, which at a pressure of 0.5 atm, injects ~ 30% of the genome length from the capsid. The principle of the reaction framework is presented as part of the assembly and packaging process. Note the diversity of genome configurations in simulations that have been studied beyond the context of reconstructions, which in itself is related to the continuity of water and ions in the simulations, and in those simulations where ions are discrete elements, configurations are Even taking into account the discretion of water in the condition should significantly increase the gap between already matched models.