ka | en
TSU

SYNTHESIS AND ENANTIOSEPERATION OF NEW CHIRAL HYDANTOINE DERIVATIVES IN HIGH PERFORMANCE LIQUID CHROMATOGRAPHY USING NORMAL MOBILE PHASES

Author: Ana Rakviashvili
Annotation:

Hydantoin derivatives are interesting compounds in terms of their pharmacological activity. Different studies have demonstrated their antiepileptic, antiarrhythmic, antidiabetic and other properties [1]. The main goal of the present study was to study a separation of enantiomers of structurally related chiral hydantoin derivatives in high-performance liquid chromatography by using polysaccharide-based chiral columns and normal-phase eluents. As mobile phases mixtures of n-hexane and propan-2-ol with various ratios were used. Dependence of retention of enantiomers and their separation on the structure of chiral compounds was studied. On the other hand, the effect of a structure of a chiral selector on its chiral recognition ability was evaluated. In addition, the enantiomer elution order of enantiomers were followed and several interesting examples of enantiomer elution order reversal based on the structure of chiral selector were observed. [1] J. C. Thenmozhiyal, P. T. H. Wong, W. K. Chui, J. Med. Chem.2004, 47, 1527–1535



Web Development by WebDevelopmentQuote.com
Design downloaded from Free Templates - your source for free web templates
Supported by Hosting24.com