SYNTHESIS AND ENANTIOSEPERATION OF NEW CHIRAL HYDANTOINE DERIVATIVES IN HIGH PERFORMANCE LIQUID CHROMATOGRAPHY USING POLAR MOBILE PHASES

Author: doni miminoshvili
Co-authors: Rusudan Kakava , Iza Matarashvili , Alesandro Volonterio , Bezhan Chankvetadze
Keywords: Hydantoin, HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Annotation:

Hydantoin derivatives are interesting compounds in terms of their pharmacological activity. Different studies have demonstrated their antiepileptic, antiarrhythmic, antidiabetic and other properties [1]. The main goal of the present study was to study a separation of enantiomers of structurally related chiral hydantoin derivatives in high-performance liquid chromatography by using polysaccharide-based chiral columns and polar-phase eluents. As mobile phases acetonitrile and methanol were used. Dependence of retention of enantiomers and their separation on the structure of chiral compounds was studied. On the other hand, the effect of a structure of a chiral selector on its chiral recognition ability was evaluated. In addition, the enantiomer elution order of enantiomers were followed and several interesting examples of enantiomer elution order reversal based on the structure of chiral selector were observed.