“Impact of Chronic Stress on Functionality of Brain Anti-Oxidant System”

In the modern world, stress has become a global problem. This is caused by its negative impact on cellular metabolism and several pathological changes formed as a result. Disruption of cellular metabolism caused by chronic emotional stress is manifested by the impact of stress factors on the body's biochemical indicators. According to studies published in recent years, long-term effects of stressors have a negative impact on the general state of the body, which is manifested in several neurodegenerative disorders, immune system pathologies, and cardiovascular diseases. The changes caused by stress involve - an increase in lipid peroxidation, a decrease in energy metabolism, changes in the course of antioxidant system and enzymatic reactions, and other negative processes. Our work aimed to determine the number of active molecules in the brain cells of experimental animals under conditions of long-term psycho-emotional stress, and then to study the functional state of this system using the example of changes in the activity of some enzymes of the antioxidant system. It was observed that in the conditions of 30-day social isolation and circadian rhythm disturbance, there is an increase in the amount of Ca2+ ions and nitric oxide in brain cells. At the same time, there is a decrease in the enzymatic activity of the antioxidant system. The obtained data give us the basis to assume that chronic stress caused by 30 days of social isolation affects the functional state of the antioxidant system of the brain.