Chemical aspects of lipid nanostructure of complex of calcium gluconate and dipalmitoylphosphatidylcholine

Liposomes are used as biological cell membrane models. An interesting aspect of their structure is the concentric spherical vesicles connected to each other, in which the volume of water is placed in the lipid bilayer of the membrane. Liposomes are currently widely used as objects of study in medicine, biotechnology, genetic engineering, biology, mathematics, and theoretical physics. Most importantly, liposomes have already appeared in the pharmaceutical industry as drug delivery systems. We have chosen DPPC (dipalmitoylphosphatidylcholine) phospholipids, which form bilayer (artificial cell membrane) nanosized liposomes, where the necessary chemical bonds are present to obtain nanosized bilayered particles. New technology was used in the laboratory to create complex calcium nanoparticles. Studies were conducted, the purpose of which was to determine what chemical connections are necessary to obtain spherical nanoparticles. The well-known calcium gluconate salt was used as the calcium salt. DPPC with calcium gluconate and their nanoparticles were studied by the calorimetric method. In this method, a heat absorption peak is obtained for the suspension of liposomal nanoparticles, which, in our opinion, should be related to the breaking of hydrogen bonds in the heads of liposomes. We have made liposomes using complex gluconate and DPPC, which is important because it can be used for the treatment and prevention of osteoporosis, and rickets. My participation in these studies was determined by the chemical aspects of the calcium complex by determining the probability of formation of hydrogen bonds between chemical groups, which explains the values of parameters obtained in calorimetric studies in physical experiments. Our chemical approaches turned out to be very close to the characteristics obtained in physical studies, which is one of the most important results of the paper.

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